The Frank lab develops light-sensitive chemical probes to manipulate lipid signaling in excitable cells of the brain and endocrine pancreas. We synthesize photo-switchable and photocaged ligands to place cannabinoid receptor (CBR) signaling under the control of light. We employ our probes alongside electrophysiology, fluorescence imaging, and fiber photometry to investigate how cannabinoid signaling and metabolism affect glucose homeostasis and sugar consumption.